Целиакия и чувствительность к глютену, не связанная с целиакией
Перевод научной статьи Celiac disease and non-celiac gluten sensitivity
BMJ. 2015; 351: h4347. Published online 2015 Oct 5. doi: 10.1136/bmj.h4347 PMCID: PMC4596973 PMID: 26438584. State of the Art Review. Benjamin Lebwohl, assistant professor of medicine and epidemiology,1,2
Jonas F Ludvigsson, professor,2,3 and Peter H R Green, professor of medicine1
Перевод Г.Е. Заика – 13 апреля 2022
Авторское предисловие к статье–Переводу «Целиакия».
Опубликованная 4 января 2022 года в Journal оf Clinical Medicine, 2022 Jan; 11(1): 258. Published online 2022 Jan 4. doi:10.3390/jcm11010258, научная статья Marilena Durazzo et al. «Extra-Intestinal Manifestations of Celiac Disease: What Should We Know in 2022? (Внекишечные проявления целиакии: что мы должны знать в 2022 году?)» имеет целью облегчить диагностику целиакии, особенно её «немых» и нетипичных форм, которая может быть ассоциирована с целым рядом самых разнообразных заболеваний, что делает статью полезной для врачей различных специальностей.
Авторы статьи обращают внимание на необходимость обследования на целиакию при наличии перечисленных в статье заболеваний, многие из которых чрезвычайно трудны для лечения*, особенно в тех случаях, когда они не поддаются общепринятой терапии. При наличии связи с целиакией, эти болезни и синдромы, как правило, поддаются строгой безглютеновой диете.
*Это, в первую очередь, очаговая алопеция, хроническая крапивница, некоторые формы атопического дерматита, герпетиформный дерматит, псориаз, другие разнообразные изменения кожных покровов, рецидивирующий афтозный стоматит, изменения эмали зубов, мозжечковая атаксия, эпилепсия и аутизм, когнитивные расстройства, головные боли и некоторые др.
Вклад авторов: All three authors participated in all four components of authorship: the conception or design of the work; the acquisition, analysis, or interpretation of data for the work; drafting the work or revising it critically for important intellectual content; and final approval of the version to be published. Agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. PHRG is guarantor.
Финансирование: BL: National Center for Advancing Translational Sciences, National Institutes of Health (UL1 TR000040). JFL: Örebro University Hospital, Karolinska Institutet, the Swedish Society of Medicine, the Swedish Research Council—Medicine (522-2A09-195), and the Swedish Coeliac Society.
Конкурирующие интересы: We have read and understood BMJ policy on declaration of interests and declare the following interests: PHRG serves on the scientific advisory boards of Alvine Pharmaceuticals and ImmusanT. The other authors have no competing interests.
Происхождение и экспертная оценка: Commissioned; externally peer reviewed.
Заметки
Цитируется как: BMJ 2015;351:h4347
References
1. Rubio-Tapia A, Ludvigsson JF, Brantner TL, et al. The prevalence of celiac disease in the United States. Am J Gastroenterol 2012;107:1538-44. [PubMed] [Google Scholar]
2. Ludvigsson JF, Montgomery SM, Ekbom A, et al. Small-intestinal histopathology and mortality risk in celiac disease. JAMA 2009;302:1171-8. [PubMed] [Google Scholar]
3. Rubio-Tapia A, Kyle RA, Kaplan EL, et al. Increased prevalence and mortality in undiagnosed celiac disease. Gastroenterology 2009;137:88-93. [PMC free article] [PubMed] [Google Scholar]
4. Ludvigsson JF, Leffler DA, Bai JC, et al. The Oslo definitions for coeliac disease and related terms. Gut 2013;62:43-52. [PMC free article] [PubMed] [Google Scholar]
5. Sapone A, Bai JC, Ciacci C, et al. Spectrum of gluten-related disorders: consensus on new nomenclature and classification. BMC Med 2012;10:13. [PMC free article] [PubMed] [Google Scholar]
6. Carlsson AK, Axelsson IE, Borulf SK, et al. Serological screening for celiac disease in healthy 2.5-year-old children in Sweden. Pediatrics 2001;107:42-5. [PubMed] [Google Scholar]
7. Myleus A, Ivarsson A, Webb C, et al. Celiac disease revealed in 3% of Swedish 12-year-olds born during an epidemic. J Pediatr Gastroenterol Nutr 2009;49:170-6. [PubMed] [Google Scholar]
8. Vilppula A, Collin P, Maki M, et al. Undetected coeliac disease in the elderly: a biopsy-proven population-based study. Dig Liver Dis 2008;40:809-13. [Pub Med] [Goo gle Scholar]
9. Dube C, Rostom A, Sy R, et al. The prevalence of celiac disease in average-risk and at-risk Western European populations: a systematic review. Gastro enterology 2005;128:S57-67. [PubMed] [Google Scholar]
10. Kang JY, Kang AH, Green A, et al. Systematic review: worldwide variation in the frequency of coeliac disease and changes over time. Aliment Pharmacol Ther 2013;38:226-45. [PubMed] [Google Scholar]
11. Katz KD, Rashtak S, Lahr BD, et al. Screening for celiac disease in a north american population: sequential serology and gastrointestinal symptoms. Am J Gastroenterol 2011;106:1333-9. [PMC free article] [PubMed] [Google Scholar]
12. Fasano A, Berti I, Gerarduzzi T, et al. Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study. Arch Intern Med 2003;163:286-92. [PubMed] [Google Scholar]
13. Mardini HE, Westgate P, Grigorian AY. Racial differences in the prevalence of celiac disease in the US population: National Health and Nutrition Examination Survey (NHANES) 2009-2012. Dig Dis Sci 2015;60:1738-42. [PubMed] [Google Scholar]
14. West J, Fleming KM, Tata LJ, et al. Incidence and prevalence of celiac disease and dermatitis herpetiformis in the UK over two decades: population-based study. Am J Gastroenterol 2014;109:757-68. [PMC free article] [PubMed] [Google Scholar]
15. Mustalahti K, Catassi C, Reunanen A, et al. The prevalence of celiac disease in Europe: results of a centralized, international mass screening project. Ann Med 2010;42:587-95. [PubMed] [Google Scholar]
16. Yuan J, Gao J, Li X, et al. The tip of the “celiac iceberg” in China: a systematic review and meta-analysis. PLoS One 2013;8:e81151. [PMC free article] [PubMed] [Google Scholar]
17. Makharia GK, Verma AK, Amarchand R, et al. Prevalence of celiac disease in the northern part of India: a community based study. J Gastroenterol Hepatol 2011;26:894-900. [PubMed] [Google Scholar]
18. Cataldo F, Lio D, Simpore J, et al. Consumption of wheat foodstuffs not a risk for celiac disease occurrence in burkina faso. J Pediatr Gastroenterol Nutr 2002;35:233-4. [PubMed] [Google Scholar]
19. Ludvigsson JF, Brandt L, Montgomery SM, et al. Validation study of villous atrophy and small intestinal inflammation in Swedish biopsy registers. BMC Gastroenterol 2009;9:19. [PMC free article] [PubMed] [Google Scholar]
20. Abdul Sultan A, Crooks CJ, Card T, et al. Causes of death in people with coeliac disease in England compared with the general population: a competing risk analysis. Gut 2015;64:1220-6. [PMC free article] [PubMed] [Google Scholar]
21. Ivarsson A, Persson LA, Nystrom L, et al. Epidemic of coeliac disease in Swedish children [see comments]. Acta Paediatr 2000;89:165-71. [PubMed] [Google Scholar]
22. Lohi S, Mustalahti K, Kaukinen K, et al. Increasing prevalence of coeliac disease over time. Aliment Pharmacol Ther 2007;26:1217-25. [PubMed] [Google Scholar]
23. Catassi C, Kryszak D, Bhatti B, et al. Natural history of celiac disease autoimmunity in a USA cohort followed since 1974. Ann Med 2010;42:530-8. [PubMed] [Google Scholar]
24. Biagi F, Campanella J, Bianchi PI, et al. The incidence of coeliac disease in adult first degree relatives. Dig Liver Dis 2008;40:97-100. [PubMed] [Google Scholar]
25. Vriezinga SL, Auricchio R, Bravi E, et al. Randomized feeding intervention in infants at high risk for celiac disease. N Engl J Med 2014;371:1304-15. [PubMed] [Google Scholar]
26. Lionetti E, Castellaneta S, Francavilla R, et al. Introduction of gluten, HLA status, and the risk of celiac disease in children. N Engl J Med 2014;371:1295-303. [PubMed] [Google Scholar]
27. Murray JA, Van Dyke C, Plevak MF, et al. Trends in the identification and clinical features of celiac disease in a North American community, 1950-2001. Clin Gastroenterol Hepatol 2003;1:19-27. [PubMed] [Google Scholar]
28. Ludvigsson JF, Rubio-Tapia A, van Dyke CT, et al. Increasing incidence of celiac disease in a north American population. Am J Gastroenterol 2013;108:818-24. [PMC free article] [PubMed] [Google Scholar]
29. Nistico L, Fagnani C, Coto I, et al. Concordance, disease progression, and heritability of coeliac disease in Italian twins. Gut 2006;55:803-8. [PMC free article] [PubMed] [Google Scholar]
30. Catassi C, Ratsch IM, Gandolfi L, et al. Why is coeliac disease endemic in the people of the Sahara? Lancet 1999;354:647-8. [PubMed] [Google Scholar]
31. Ivarsson A, Hernell O, Stenlund H, et al. Breast-feeding protects against celiac disease. Am J Clin Nutr 2002;75:914-21. [PubMed] [Google Scholar]
32. Roberts SE, Williams JG, Meddings D, et al. Perinatal risk factors and coeliac disease in children and young adults: a record linkage study. Aliment Pharmacol Ther 2009;29:222-31. [PubMed] [Google Scholar]
33. Welander A, Tjernberg AR, Montgomery SM, et al. Infectious disease and risk of later celiac disease in childhood. Pediatrics 2010;125:e530-6. [PubMed] [Google Scholar]
34. Aronsson CA, Lee HS, Liu E, et al. Age at gluten introduction and risk of celiac disease. Pediatrics 2015;135:239-45. [PMC free article] [PubMed] [Google Scholar]
35. Marild K, Stephansson O, Montgomery S, et al. Pregnancy outcome and risk of celiac disease in offspring: a nationwide case-control study. Gastroenterology 2012;142:39-45.e3. [PMC free article] [PubMed] [Google Scholar]
36. Hyoty H, Hiltunen M, Knip M, et al. A prospective study of the role of coxsackie B and other enterovirus infections in the pathogenesis of IDDM. Childhood Diabetes in Finland (DiMe) Study Group. Diabetes 1995;44:652-7. [PubMed] [Google Scholar]
37. Kagnoff MF, Paterson YJ, Kumar PJ, et al. Evidence for the role of a human intestinal adenovirus in the pathogenesis of coeliac disease. Gut 1987;28:995-1001. [PMC free article] [PubMed] [Google Scholar]
38. Stene LC, Honeyman MC, Hoffenberg EJ, et al. Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: a longitudinal study. Am J Gastroenterol 2006;101:2333-40. [PubMed] [Google Scholar]
39. Riddle MS, Murray JA, Porter CK. The incidence and risk of celiac disease in a healthy US adult population. Am J Gastroenterol 2012;107:1248-55. [PMC free article] [PubMed] [Google Scholar]
40. Decker E, Engelmann G, Findeisen A, et al. Cesarean delivery is associated with celiac disease but not inflammatory bowel disease in children. Pediatrics 2010;125:e1433-40. [PubMed] [Google Scholar]
41. Lebwohl B, Blaser MJ, Ludvigsson JF, et al. Decreased risk of celiac disease in patients with Helicobacter pylori colonization. Am J Epidemiol 2013;178:1721-30. [PMC free article] [PubMed] [Google Scholar]
42. Austin AS, Logan RF, Thomason K, et al. Cigarette smoking and adult coeliac disease. Scand J Gastroenterol 2002;37:978-82. [PubMed] [Google Scholar]
43. Snook JA, Dwyer L, Lee-Elliott C, et al. Adult coeliac disease and cigarette smoking [see comments]. Gut 1996;39:60-2. [PMC free article] [PubMed] [Google Scholar]
44. Vazquez H, Smecuol E, Flores D, et al. Relation between cigarette smoking and celiac disease: evidence from a case-control study. Am J Gastroenterol 2001;96:798-802. [PubMed] [Google Scholar]
45. Ludvigsson JF, Montgomery SM, Ekbom A. Smoking and celiac disease: a population-based cohort study. Clin Gastroenterol Hepatol 2005;3:869-74. [PubMed] [Google Scholar]
46. Lebwohl B, Spechler SJ, Wang TC, et al. Use of proton pump inhibitors and subsequent risk of celiac disease. Dig Liver Dis 2014;46:36-40. [PMC free article] [PubMed] [Google Scholar]
47. Marild K, Ye W, Lebwohl B, et al. Antibiotic exposure and the development of coeliac disease: a nationwide case-control study. BMC Gastroenterol 2013;13:109. [PMC free article] [PubMed] [Google Scholar]
48. Lundin KE, Scott H, Hansen T, et al. Gliadin-specific, HLA-DQ(alpha 1*0501,beta 1*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients. J Exp Med 1993;178:187-96. [PMC free article] [PubMed] [Google Scholar]
49. Green PH, Lebwohl B, Greywoode R. Celiac disease. J Allergy Clin Immunol 2015;135:1099-106; quiz 1107. [PubMed] [Google Scholar]
50. Shan L, Molberg O, Parrot I, et al. Structural basis for gluten intolerance in celiac sprue. Science 2002;297:2275-9. [PubMed] [Google Scholar]
51. Matysiak-Budnik T, Moura IC, Arcos-Fajardo M, et al. Secretory IgA mediates retrotranscytosis of intact gliadin peptides via the transferrin receptor in celiac disease. T J Exp Med 2008;205:143-54. [PMC free article] [PubMed] [Google Scholar]
52. Visser J, Rozing J, Sapone A, et al. Tight junctions, intestinal permeability, and autoimmunity: celiac disease and type 1 diabetes paradigms. Ann N Y Acad Sci 2009;1165:195-205. [PMC free article] [PubMed] [Google Scholar]
53. Sollid LM. Coeliac disease: dissecting a complex inflammatory disorder. Nat Rev Immunol 2002;2:647-55. [PubMed] [Google Scholar]
54. Nilsen EM, Jahnsen FL, Lundin KE, et al. Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with celiac disease. Gastroenterology 1998;115:551-63. [PubMed] [Google Scholar]
55. Mohamed BM, Feighery C, Kelly J, et al. Increased protein expression of matrix metalloproteinases -1, -3, and -9 and TIMP-1 in patients with gluten-sensitive enteropathy. Dig Dis Sci 2006;51:1862-8. [PubMed] [Google Scholar]
56. Taylor TB, Schmidt LA, Meyer LJ, et al. Transglutaminase 3 present in the IgA aggregates in dermatitis herpetiformis skin is enzymatically active and binds soluble fibrinogen. J Invest Dermatol 2015;135:623-5. [PubMed] [Google Scholar]
57. Mention JJ, Ben Ahmed M, Begue B, et al. Interleukin 15: a key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease. Gastroenterology 2003;125:730-45. [PubMed] [Google Scholar]
58. Tang F, Chen Z, Ciszewski C, et al. Cytosolic PLA2 is required for CTL-mediated immunopathology of celiac disease via NKG2D and IL-15. J Exp Med 2009;206:707-19. [PMC free article] [PubMed] [Google Scholar]
59. Junker Y, Zeissig S, Kim SJ, et al. Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4. J Exp Med 2012;209:2395-408. [PMC free article] [PubMed] [Google Scholar]
60. Rampertab SD, Pooran N, Brar P, et al. Trends in the presentation of celiac disease. Am J Med 2006;119:355 e9-14. [PubMed] [Google Scholar]
61. Reilly NR, Aguilar K, Hassid BG, et al. Celiac disease in normal-weight and overweight children: clinical features and growth outcomes following a gluten-free diet. J Pediatr Gastroenterol Nutr 2011;53:528-31. [PubMed] [Google Scholar]
62. Rizkalla Reilly N, Dixit R, Simpson S, et al. Celiac disease in children: an old disease with new features. Minerva Pediatr 2012;64:71-81. [PubMed] [Google Scholar]
63. Harper JW, Holleran SF, Ramakrishnan R, et al. Anemia in celiac disease is multifactorial in etiology. Am J Hematol 2007;82:996-1000. [PubMed] [Google Scholar]
64. Sanders DS, Hopper AD, Azmy IA, et al. Association of adult celiac disease with surgical abdominal pain: a case-control study in patients referred to secondary care. Ann Surg 2005;242:201-7. [PMC free article] [PubMed] [Google Scholar]
65. Hadjivassiliou M, Duker AP, Sanders DS. Gluten-related neurologic dysfunction. Handb Clin Neurol 2014;120:607-19. [PubMed] [Google Scholar]
66. Volta U, Caio G, Stanghellini V, et al. The changing clinical profile of celiac disease: a 15-year experience (1998-2012) in an Italian referral center. BMC Gastroenterol 2014;14:194. [PMC free article] [PubMed] [Google Scholar]
67. Green PH, Cellier C. Celiac disease. N Engl J Med 2007;357:1731-43. [PubMed] [Google Scholar]
68. Nachman F, Vazquez H, Gonzalez A, et al. Gastroesophageal reflux symptoms in patients with celiac disease and the effects of a gluten-free diet. Clin Gastroenterol Hepatol 2011;9:214-9. [PubMed] [Google Scholar]
69. Cheng J, Brar PS, Lee AR, et al. Body mass index in celiac disease: beneficial effect of a gluten-free diet. J Clin Gastroenterol 2010;44:267-71. [PubMed] [Google Scholar]
70. Kabbani TA, Goldberg A, Kelly CP, et al. Body mass index and the risk of obesity in coeliac disease treated with the gluten-free diet. Aliment Pharmacol Ther 2012;35:723-9. [PubMed] [Google Scholar]
71. Dixit R, Lebwohl B, Ludvigsson JF, et al. Celiac disease is diagnosed less frequently in young adult males. Dig Dis Sci 2014;59:1509-12. [PubMed] [Google Scholar]
72. Hill ID, Dirks MH, Liptak GS, et al. Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr 2005;40:1-19. [PubMed] [Google Scholar]
73. NIH Consensus Development Conference on Celiac Disease. http://consensus.nih.gov/2004/2004CeliacDisease118html.htm.
74. Ludvigsson JF, Bai JC, Biagi F, et al. Diagnosis and management of adult coeliac disease: guidelines from the British Society of Gastroenterology. Gut 2014;63:1210-28. [PMC free article] [PubMed] [Google Scholar]
75. Peters U, Askling J, Gridley G, et al. Causes of death in patients with celiac disease in a population-based Swedish cohort. Arch Intern Med 2003;163:1566-72. [PubMed] [Google Scholar]
76. West J, Logan RF, Smith CJ, et al. Malignancy and mortality in people with coeliac disease: population based cohort study. BMJ 2004;329:716-9. [PMC free article] [PubMed] [Google Scholar]
77. Elfstrom P, Granath F, Ekstrom Smedby K, et al. Risk of lymphoproliferative malignancy in relation to small intestinal histopathology among patients with celiac disease. J Natl Cancer Inst 2011;103:436-44. [PubMed] [Google Scholar]
78. Tio M, Cox MR, Eslick GD. Meta-analysis: coeliac disease and the risk of all-cause mortality, any malignancy and lymphoid malignancy. Aliment Pharmacol Ther 2012;35:540-51. [PubMed] [Google Scholar]
79. Ilus T, Kaukinen K, Virta LJ, et al. Incidence of malignancies in diagnosed celiac patients: a population-based estimate. Am J Gastroenterol 2014;109:1471-7. [PubMed] [Google Scholar]
80. Lebwohl B, Granath F, Ekbom A, et al. Mucosal healing and risk for lymphoproliferative malignancy in celiac disease: a population-based cohort study. Ann Intern Med 2013;159:169-75. [PMC free article] [PubMed] [Google Scholar]
81. Elfstrom P, Granath F, Ye W, et al. Low risk of gastrointestinal cancer among patients with celiac disease, inflammation, or latent celiac disease. Clin Gastroenterol Hepatol 2012;10:30-6. [PubMed] [Google Scholar]
82. Ludvigsson JF, Fall K, Montgomery S. Risk of prostate cancer in a population-based cohort of men with coeliac disease. Br J Cancer 2012;106:217-21. [PMC free article] [PubMed] [Google Scholar]
83. Ludvigsson JF, West J, Ekbom A, et al. Reduced risk of breast, endometrial and ovarian cancer in women with celiac disease. Int J Cancer 2012;131:E244-50. [PubMed] [Google Scholar]
84. Gutierrez-Achury J, Coutinho de Almeida R, Wijmenga C. Shared genetics in coeliac disease and other immune-mediated diseases. J Intern Med 2011;269:591-603. [PubMed] [Google Scholar]
85. Van Heel DA, Franke L, Hunt KA, et al. A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21. Nat Genet 2007;39:827-9. [PMC free article] [PubMed] [Google Scholar]
86. Smyth DJ, Plagnol V, Walker NM, et al. Shared and distinct genetic variants in type 1 diabetes and celiac disease. N Engl J Med 2008;359:2767-77. [PMC free article] [PubMed] [Google Scholar]
87. Hadithi M, de Boer H, Meijer JW, et al. Coeliac disease in Dutch patients with Hashimoto’s thyroiditis and vice versa. World J Gastroenterol 2007;13:1715-22. [PMC free article] [PubMed] [Google Scholar]
88. Elfstrom P, Montgomery SM, Kampe O, et al. Risk of thyroid disease in individuals with celiac disease. J Clin Endocrinol Metab 2008;93:3915-21. [PubMed] [Google Scholar]
89. Aggarwal S, Lebwohl B, Green PH. Screening for celiac disease in average-risk and high-risk populations. Ther Adv Gastroenterol 2012;5:37-47. [PMC free article] [PubMed] [Google Scholar]
90. Mirzaagha F, Azali SH, Islami F, et al. Coeliac disease in autoimmune liver disease: a cross-sectional study and a systematic review. Dig Liver Dis 2010;42:620-3. [PubMed] [Google Scholar]
91. Kaukinen K, Halme L, Collin P, et al. Celiac disease in patients with severe liver disease: gluten-free diet may reverse hepatic failure. Gastroenterology 2002;122:881-8. . [PubMed] [Google Scholar]
92. Sadr-Azodi O, Sanders DS, Murray JA, et al. Patients with celiac disease have an increased risk for pancreatitis. Clin Gastroenterol Hepatol 2012;10:1136-42 e3. [PMC free article] [PubMed] [Google Scholar]
93. Evans KE, Leeds JS, Morley S, et al. Pancreatic insufficiency in adult celiac disease: do patients require long-term enzyme supplementation? Dig Dis Sci 2010;55:2999-3004. [PubMed] [Google Scholar]
94. Volta U, De Franceschi L, Lari F, et al. Coeliac disease hidden by cryptogenic hypertransaminasaemia. Lancet 1998;352:26-9. [PubMed] [Google Scholar]
95. Sorensen HT, Thulstrup AM, Blomqvist P, et al. Risk of primary biliary liver cirrhosis in patients with coeliac disease: Danish and Swedish cohort data. Gut 1999;44:736-8. [PMC free article] [PubMed] [Google Scholar]
96. Ludvigsson JF, James S, Askling J, et al. Nationwide cohort study of risk of ischemic heart disease in patients with celiac disease. Circulation 2011;123:483-90. [PubMed] [Google Scholar]
97. Emilsson L, Carlsson R, Holmqvist M, et al. The characterisation and risk factors of ischaemic heart disease in patients with coeliac disease. Aliment Pharmacol Ther 2013;37:905-14. [PubMed] [Google Scholar]
98. West J, Logan RF, Card TR, et al. Risk of vascular disease in adults with diagnosed coeliac disease: a population-based study. Aliment Pharmacol Ther 2004;20:73-9. [PubMed] [Google Scholar]
99. West J, Logan RF, Hill PG, et al. Seroprevalence, correlates, and characteristics of undetected coeliac disease in England. Gut 2003;52:960-5. [PMC free article] [PubMed] [Google Scholar]
100. Grainge MJ, West J, Card TR, et al. Causes of death in people with celiac disease spanning the pre- and post-serology era: a population-based cohort study from Derby, UK. Am J Gastroenterol 2011;106:933-9. [PubMed] [Google Scholar]
101. Khashan AS, Henriksen TB, Mortensen PB, et al. The impact of maternal celiac disease on birthweight and preterm birth: a Danish population-based cohort study. Hum Reprod 2010;25:528-34. [PubMed] [Google Scholar]
102. Ludvigsson JF, Montgomery SM, Ekbom A. Celiac disease and risk of adverse fetal outcome: a population-based cohort study. Gastroenterology 2005;129:454-63. [PubMed] [Google Scholar]
103. Kiefte-de Jong JC, Jaddoe VW, Uitterlinden AG, et al. Levels of antibodies against tissue transglutaminase during pregnancy are associated with reduced fetal weight and birth weight. Gastroenterology 2013;144:726-35 e2. [PubMed] [Google Scholar]
104. Martinelli P, Troncone R, Paparo F, et al. Coeliac disease and unfavourable outcome of pregnancy. Gut 2000;46:332-5. [PMC free article] [PubMed] [Google Scholar]
105. Zugna D, Richiardi L, Stephansson O, et al. Risk of congenital malformations among offspring of mothers and fathers with celiac disease: a nationwide cohort study. Clin Gastroenterol Hepatol 2014;12:1108-16.e6. [PubMed] [Google Scholar]
106. Zugna D, Richiardi L, Akre O, et al. A nationwide population-based study to determine whether coeliac disease is associated with infertility. Gut 2010;59:1471-5. [PubMed] [Google Scholar]
107. Rubio-Tapia A, Rahim MW, See JA, et al. Mucosal recovery and mortality in adults with celiac disease after treatment with a gluten-free diet. Am J Gastroenterol 2010;105:1412-20. [PMC free article] [PubMed] [Google Scholar]
108. Tuire I, Marja-Leena L, Teea S, et al. Persistent duodenal intraepithelial lymphocytosis despite a long-term strict gluten-free diet in celiac disease. Am J Gastroenterol 2012;107:1563-9. [PubMed] [Google Scholar]
109. Lebwohl B, Murray JA, Rubio-Tapia A, et al. Predictors of persistent villous atrophy in coeliac disease: a population-based study. Aliment Pharmacol Ther 2014;39:488-95. [PMC free article] [PubMed] [Google Scholar]
110. Lebwohl B, Granath F, Ekbom A, et al. Mucosal healing and mortality in coeliac disease. Aliment Pharmacol Ther 2013;37:332-9. [PMC free article] [PubMed] [Google Scholar]
111. Lebwohl B, Emilsson L, Frobert O, et al. Mucosal healing and the risk of ischemic heart disease or atrial fibrillation in patients with celiac disease; a population-based study. PLoS One 2015;10:e0117529. [PMC free article] [PubMed] [Google Scholar]
112. Lebwohl B, Stephansson O, Green PH, et al. Mucosal healing in patients with celiac disease and outcomes of pregnancy: a nationwide population-based study. Clin Gastroenterol Hepatol 2015;13:1111-7. [PMC free article] [PubMed] [Google Scholar]
113. Lebwohl B, Michaelsson K, Green PH, et al. Persistent mucosal damage and risk of fracture in celiac disease. J Clin Endocrinol Metab 2014;99:609-16. [PMC free article] [PubMed] [Google Scholar]
114. Sharkey LM, Corbett G, Currie E, et al. Optimising delivery of care in coeliac disease—comparison of the benefits of repeat biopsy and serological follow-up. Aliment Pharmacol Ther 2013;38:1278-91. [PubMed] [Google Scholar]
115. Rubio-Tapia A, Hill ID, Kelly CP, et al; American College of Gastroenterology. ACG clinical guidelines: diagnosis and management of celiac disease. Am J Gastroenterol 2013;108:656-76; quiz 77. [PMC free article] [PubMed] [Google Scholar]
116. Murray JA, Watson T, Clearman B, et alF. Effect of a gluten-free diet on gastrointestinal symptoms in celiac disease. Am J Clin Nutr 2004;79:669-73. [PubMed] [Google Scholar]
117. Lee AR, Ng DL, Zivin J, Green PH. Economic burden of a gluten-free diet. J Hum Nutr Diet 2007;20:423-30. [PubMed] [Google Scholar]
118. Shah S, Akbari M, Vanga R, et al. Patient perception of treatment burden is high in celiac disease compared with other common conditions. Am J Gastroenterol 2014;109:1304-11. [PMC free article] [PubMed] [Google Scholar]
119. Leffler DA, Dennis M, Hyett B, et al. Etiologies and predictors of diagnosis in nonresponsive celiac disease. Clin Gastroenterol Hepatol 2007;5:445-50. [PubMed] [Google Scholar]
120. Tennyson CA, Simpson S, Lebwohl B, et al. Interest in medical therapy for celiac disease. Ther Adv Gastroenterol 2013;6:358-64. [PMC free article] [PubMed] [Google Scholar]
121. Mukherjee R, Kelly CP, Schuppan D. Nondietary therapies for celiac disease. Gastointest Endosc Clin N Am 2012;22:811-31. [PubMed] [Google Scholar]
122. Leffler DA, Kelly CP, Abdallah HZ, et al. A randomized, double-blind study of larazotide acetate to prevent the activation of celiac disease during gluten challenge. Am J Gastroenterol 2012;107:1554-62. [PMC free article] [PubMed] [Google Scholar]
123. Kelly CP, Green PH, Murray JA, et al. Larazotide acetate in patients with coeliac disease undergoing a gluten challenge: a randomised placebo-controlled study. Aliment Pharmacol Ther 2013;37:252-62. [PubMed] [Google Scholar]
124. Lahdeaho ML, Kaukinen K, Laurila K, et al. Glutenase ALV003 attenuates gluten-induced mucosal injury in patients with celiac disease. Gastroenterology 2014;146:1649-58. [PubMed] [Google Scholar]
125. Catassi C, Bai JC, Bonaz B, et al. Non-celiac gluten sensitivity: the new frontier of gluten related disorders. Nutrients 2013;5:3839-53. [PMC free article] [PubMed] [Google Scholar]
126. Aziz I, Lewis NR, Hadjivassiliou M, et al. A UK study assessing the population prevalence of self-reported gluten sensitivity and referral characteristics to secondary care. Eur J Gastroenterol Hepatol 2014;26:33-9. [PubMed] [Google Scholar]
127. Golley S, Corsini N, Topping D, et al. Motivations for avoiding wheat consumption in Australia: results from a population survey. Public Health Nutr 2015;18:490-9. [PubMed] [Google Scholar]
128. Digiacomo DV, Tennyson CA, Green PH, et al. Prevalence of gluten-free diet adherence among individuals without celiac disease in the USA: results from the continuous national health and nutrition examination survey 2009-2010. Scand J Gastroenterol 2013;48:921-5. [PubMed] [Google Scholar]
129. Volta U, Bardella MT, Calabro A, et al. An Italian prospective multicenter survey on patients suspected of having non-celiac gluten sensitivity. BMC Med 2014;12:85. [PMC free article] [PubMed] [Google Scholar]
130. Lis D, Stellingwerff T, Shing CM, et al. Exploring the popularity, experiences and beliefs surrounding gluten-free diets in non-coeliac athletes. Int J Sport Nutr Exerc Metab 2015;25:37-45. [PubMed] [Google Scholar]
131. Ellis A, Linaker BD. Non-coeliac gluten sensitivity? Lancet 1978;1:1358-9. [PubMed] [Google Scholar]
132. Cooper BT, Holmes GK, Ferguson R, et al. Gluten-sensitive diarrhea without evidence of celiac disease. Gastroenterology 1980;79:801-6. [PubMed] [Google Scholar]
133. Tavakkoli A, Lewis SK, Tennyson CA, et al. Characteristics of patients who avoid wheat and/or gluten in the absence of celiac disease. Dig Dis Sci 2014;59:1255-61. [PubMed] [Google Scholar]
134. Biesiekierski JR, Newnham ED, Shepherd SJ, et al. Characterization of adults with a self-diagnosis of nonceliac gluten sensitivity. Nutr Clin Pract 2014;29:504-9. [PubMed] [Google Scholar]
135. Brottveit M, Beitnes AC, Tollefsen S, et al. Mucosal cytokine response after short-term gluten challenge in celiac disease and non-celiac gluten sensitivity. Am J Gastroenterol 2013;108:842-50. [PubMed] [Google Scholar]
136. Biesiekierski JR, Newnham ED, Irving PM, et al. Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial. Am J Gastroenterol 2011;106:508-14. [PubMed] [Google Scholar]
137. Vazquez-Roque MI, Camilleri M, Smyrk T, et al. A controlled trial of gluten-free diet in patients with irritable bowel syndrome-diarrhea: effects on bowel frequency and intestinal function. Gastroenterology 2013;144:903-11.e3. [PMC free article] [PubMed] [Google Scholar]
138. Biesiekierski JR, Peters SL, Newnham ED, et al. No effects of gluten in patients with self-reported non-celiac gluten sensitivity after dietary reduction of fermentable, poorly absorbed, short-chain carbohydrates. Gastroenterology 2013;145:320-8.e1-3. [PubMed] [Google Scholar]
139. Di Sabatino A, Volta U, Salvatore C, et al. Small amounts of gluten in subjects with suspected nonceliac gluten sensitivity: a randomized, double-blind, placebo-controlled, cross-over trial. Clin Gastroenterol Hepatol 2015; published online 19 Feb. [PubMed]
140. Hollon J, Puppa EL, Greenwald B, et al. Effect of gliadin on permeability of intestinal biopsy explants from celiac disease patients and patients with non-celiac gluten sensitivity. Nutrients 2015;7:1565-76. [PMC free article] [PubMed] [Google Scholar]
141. Sapone A, Lammers KM, Casolaro V, et al. Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity. BMC Med 2011;9:23. [PMC free article] [PubMed] [Google Scholar]
142. Huebener S, Tanaka CK, Uhde M, et al. Specific nongluten proteins of wheat are novel target antigens in celiac disease humoral response. J Proteome Res 2015;14:503-11. [PMC free article] [PubMed] [Google Scholar]
143. Caio G, Volta U, Tovoli F, et al. Effect of gluten free diet on immune response to gliadin in patients with non-celiac gluten sensitivity. BMC Gastroenterol 2014;14:26. [PMC free article] [PubMed] [Google Scholar]
144. Eaton WW, Byrne M, Ewald H, et al. Association of schizophrenia and autoimmune diseases: linkage of danish national registers. Am J Psychiatry 2006;163:521-8. [PubMed] [Google Scholar]
145. Chin RL, Sander HW, Brannagan TH, et al. Celiac neuropathy. Neurology 2003;60:1581-5. [PubMed] [Google Scholar]
146. Cascella NG, Kryszak D, Bhatti B, et al. Prevalence of celiac disease and gluten sensitivity in the United States clinical antipsychotic trials of intervention effectiveness study population. Schizophr Bull 2011;37:94-100. [PMC free article] [PubMed] [Google Scholar]
147. Samaroo D, Dickerson F, Kasarda DD, et al. Novel immune response to gluten in individuals with schizophrenia. Schizophr Res 2010;118:248-55. [PMC free article] [PubMed] [Google Scholar]
148. Dickerson F, Stallings C, Origoni A, et al. Markers of gluten sensitivity and celiac disease in recent-onset psychosis and multi-episode schizophrenia. Biol Psychiatry 2010;68:100-4. [PubMed] [Google Scholar]
149. Lau NM, Green PH, Taylor AK, et al. Markers of celiac disease and gluten sensitivity in children with autism. PLoS One 2013;8:e66155. [PMC free article] [PubMed] [Google Scholar]
150. Ludvigsson JF, Reichenberg A, Hultman CM, et al. A nationwide study of the association between celiac disease and the risk of autistic spectrum disorders. JAMA Psychiatry 2013;70:1224-30. [PMC free article] [PubMed] [Google Scholar]
151. Ludvigsson JF, Green PH. The missing environmental factor in celiac disease. N Engl J Med 2014;371:1341-3. [PubMed] [Google Scholar]
152. Lebwohl B, Ludvigsson JF, Green PH. The unfolding story of celiac disease risk factors. Clin Gastroenterol Hepatol 2014;12:632-5. [PMC free article] [PubMed] [Google Scholar]
153. Nadal I, Donat E, Ribes-Koninckx C, et al. Imbalance in the composition of the duodenal microbiota of children with coeliac disease. J Med Microbiol 2007;56:1669-74. [PubMed] [Google Scholar]
154. Olivares M, Neef A, Castillejo G, et al. The HLA-DQ2 genotype selects for early intestinal microbiota composition in infants at high risk of developing coeliac disease. Gut 2015;64:406-17. [PubMed] [Google Scholar]
155. Simell S, Hoppu S, Hekkala A, et al. Fate of five celiac disease-associated antibodies during normal diet in genetically at-risk children observed from birth in a natural history study. Am J Gastroenterol 2007;102:2026-35. [PubMed] [Google Scholar]
156. Mahadev S, Bhagat G, Green PH. Transient celiac autoimmunity in an adult. J Clin Gastroenterol 2011;45:912-3. [PubMed] [Google Scholar]
157. Mooney PD, Wong SH, Johnston AJ, et al. Increased detection of celiac disease with measurement of deamidated gliadin peptide antibody before endoscopy. Clin Gastroenterol Hepatol 2015;13:1278-84.e1. [PubMed] [Google Scholar]
158. Lebwohl B, Bhagat G, Markoff S, et al. Prior endoscopy in patients with newly diagnosed celiac disease: a missed opportunity? Dig Dis Sci 2013;58:1293-8. [PMC free article] [PubMed] [Google Scholar]
159. Adriaanse MP, Tack GJ, Passos VL, et al. Serum I-FABP as marker for enterocyte damage in coeliac disease and its relation to villous atrophy and circulating autoantibodies. Aliment Pharmacol Ther 2013;37:482-90. [PubMed] [Google Scholar]
160. Comino I, Real A, Vivas S, et al. Monitoring of gluten-free diet compliance in celiac patients by assessment of gliadin 33-mer equivalent epitopes in feces. Am J Clin Nutr 2012;95:670-7. [PMC free article] [PubMed] [Google Scholar]
161. Catassi C, Fabiani E, Iacono G, et al. A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease. Am J Clin Nutr 2007;85:160-6. [PubMed] [Google Scholar]
162. Fuchs V, Kurppa K, Huhtala H, et al. Factors associated with long diagnostic delay in celiac disease. Scand J Gastroenterol 2014:1-7. [PubMed]
163. Master S, Lebwohl B, Ludvigsson JF, et al. Bibliometric study of the quality of celiac disease research publications. J Pediatr Gastroenterol Nutr 2013;57:527-8. [PMC free article] [PubMed] [Google Scholar]
164. Narotsky D, Green PH, Lebwohl B. Temporal and geographic trends in celiac disease publications: a bibliometric analysis. Eur J Gastroenterol Hepatol 2012;24:1071-7. [PubMed] [Google Scholar]
165. Smukalla S, Lebwohl B, Mears JG, et al. How often do hematologists consider celiac disease in iron-deficiency anemia? Results of a national survey. Clin Adv Hematol Oncol 2014;12:100-5. [PubMed] [Google Scholar]
166. Simpson SM, Ciaccio EJ, Case S, et al. Celiac disease in patients with type 1 diabetes: screening and diagnostic practices. Diabetes Educ 2013;39:532-40. [PubMed] [Google Scholar]
167. Collin P, Huhtala H, Virta L, et al. Diagnosis of celiac disease in clinical practice: physician’s alertness to the condition essential. J Clin Gastroenterol 2007;41:152-6. [PubMed] [Google Scholar]
168. Catassi C, Kryszak D, Louis-Jacques O, et al. Detection of celiac disease in primary care: a multicenter case-finding study in North America. Am J Gastroenterol 2007;102:1454-60. [PubMed] [Google Scholar]
169. Bai JC, Fried M, Corazza GR, et al. World Gastroenterology Organisation global guidelines on celiac disease. J Clin Gastroenterol 2013;47:121-6. [PubMed] [Google Scholar]
170. Husby S, Koletzko S, Korponay-Szabo IR, et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr 2012;54:136-60. [PubMed] [Google Scholar]